抗人 ADGRE2 抗体对
01AB01002
Adhesion G protein-coupled receptor E2 (ADGRE2) is a cell surface receptor found in various immune system cells, particularly mast cells. It consists of two subunits: an alpha subunit on the cell's outer surface and a beta subunit spanning the cell membrane. ADGRE2 plays a role in cell adhesion by binding to chondroitin sulfate on glycosaminoglycan chains. The protein promotes granulocyte chemotaxis, degranulation, and adhesion, and in macrophages, it stimulates the release of inflammatory cytokines. ADGRE2 undergoes GPS autoproteolysis before reaching the plasma membrane, and its distribution within lipid rafts may affect cell signaling. A mutation in the ADGRE2 gene (Cys492Tyr) has been associated with vibratory urticaria, a condition where vibration or friction on the skin causes allergy symptoms. This mutation leads to a less stable interaction between the protein's subunits, potentially triggering mast cell reactions upon mechanical stimulation.
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技术参数
- 靶点基因名
- ADGRE2
- 基因别名
- EMR2
- 蛋白别名
- adhesion G protein-coupled receptor E2; ADGRE2
- UniProt
- Q9UHX3
- 物种
- Human
产品详情
- 靶点名称
- ADGRE2
- 蛋白名称
- adhesion G protein-coupled receptor E2
- 蛋白别名
- Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD antigen CD312
- 靶点基因名
- ADGRE2
- 基因别名
- EMR2
- UniProt
- Q9UHX3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adhesion G protein-coupled receptor E2 (ADGRE2) is a cell surface receptor found in various immune system cells, particularly mast cells. It consists of two subunits: an alpha subunit on the cell's outer surface and a beta subunit spanning the cell membrane. ADGRE2 plays a role in cell adhesion by binding to chondroitin sulfate on glycosaminoglycan chains. The protein promotes granulocyte chemotaxis, degranulation, and adhesion, and in macrophages, it stimulates the release of inflammatory cytokines. ADGRE2 undergoes GPS autoproteolysis before reaching the plasma membrane, and its distribution within lipid rafts may affect cell signaling. A mutation in the ADGRE2 gene (Cys492Tyr) has been associated with vibratory urticaria, a condition where vibration or friction on the skin causes allergy symptoms. This mutation leads to a less stable interaction between the protein's subunits, potentially triggering mast cell reactions upon mechanical stimulation.