人 ADGRB1 抗体对
01AB04208
Adhesion G protein-coupled receptor B1 (ADGRB1), also known as brain-specific angiogenesis inhibitor 1 (BAI1), is a receptor involved in various physiological processes, including angiogenesis, synaptogenesis, and macrophage function. Structurally, it features multiple thrombospondin type 1 repeats and a GAIN domain that facilitates autoproteolysis, crucial for its signaling functions. Mutations in ADGRB1 are linked to diseases such as lung cancer and neurological disorders, highlighting its role in tumor suppression and neural development. Additionally, ADGRB1 mediates the engulfment of apoptotic cells by binding to phosphatidylserine, showcasing its importance in immune responses.
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技术参数
- 靶点基因名
- ADGRB1
- 基因别名
- BAI1
- 蛋白别名
- adhesion G protein-coupled receptor B1; ADGRB1
- UniProt
- O14514
- 物种
- Human
产品详情
- 靶点名称
- ADGRB1
- 蛋白名称
- adhesion G protein-coupled receptor B1
- 蛋白别名
- Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40; Vstat40; Vasculostatin-120; Vstat120]
- 靶点基因名
- ADGRB1
- 基因别名
- BAI1
- UniProt
- O14514
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adhesion G protein-coupled receptor B1 (ADGRB1), also known as brain-specific angiogenesis inhibitor 1 (BAI1), is a receptor involved in various physiological processes, including angiogenesis, synaptogenesis, and macrophage function. Structurally, it features multiple thrombospondin type 1 repeats and a GAIN domain that facilitates autoproteolysis, crucial for its signaling functions. Mutations in ADGRB1 are linked to diseases such as lung cancer and neurological disorders, highlighting its role in tumor suppression and neural development. Additionally, ADGRB1 mediates the engulfment of apoptotic cells by binding to phosphatidylserine, showcasing its importance in immune responses.