抗人 Adenosine Deaminase 抗体对
01AB03931
Adenosine deaminase (ADA) is an essential enzyme involved in purine metabolism, catalyzing the irreversible deamination of adenosine to inosine, which is crucial for regulating intracellular and extracellular adenosine levels. ADA exists in two forms: ADA1, primarily found in lymphoid tissues, and ADA2, which has a lower abundance and is implicated in immune responses. The enzyme plays a significant role in the development and maintenance of the immune system; deficiencies in ADA can lead to severe combined immunodeficiency (SCID), characterized by an inability to produce functional immune cells. Additionally, ADA deficiency has been linked to pulmonary fibrosis and various autoimmune conditions due to the accumulation of toxic levels of adenosine.
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技术参数
- 靶点基因名
- ADA
- 基因别名
- ADA1
- 蛋白别名
- adenosine deaminase; Adenosine Deaminase
- UniProt
- P00813
- 物种
- Human
产品详情
- 靶点名称
- Adenosine Deaminase
- 蛋白名称
- adenosine deaminase
- 蛋白别名
- Adenosine deaminase; Adenosine aminohydrolase
- 靶点基因名
- ADA
- 基因别名
- ADA1
- UniProt
- P00813
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adenosine deaminase (ADA) is an essential enzyme involved in purine metabolism, catalyzing the irreversible deamination of adenosine to inosine, which is crucial for regulating intracellular and extracellular adenosine levels. ADA exists in two forms: ADA1, primarily found in lymphoid tissues, and ADA2, which has a lower abundance and is implicated in immune responses. The enzyme plays a significant role in the development and maintenance of the immune system; deficiencies in ADA can lead to severe combined immunodeficiency (SCID), characterized by an inability to produce functional immune cells. Additionally, ADA deficiency has been linked to pulmonary fibrosis and various autoimmune conditions due to the accumulation of toxic levels of adenosine.