人 ADAMTS4 抗体对
01AB00448
ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4) is a member of the ADAMTS protein family, characterized by a multi-domain structure including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. This enzyme is primarily known for its role in the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The full-length ADAMTS4 (70 kDa) is the most effective aggrecanase, but it exhibits little activity against the Glu(373)-Ala(374) bond, a signature site of aggrecanase activity. ADAMTS4 is involved in the turnover of aggrecan and may play a critical role in the destruction of aggrecan in arthritic diseases and potentially in neurodegenerative conditions such as Alzheimer's disease. Its expression is upregulated in arthritic disease, contributing to disease progression through the degradation of aggrecan.
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技术参数
- 靶点基因名
- ADAMTS4
- 基因别名
- KIAA0688
- 蛋白别名
- ADAM metallopeptidase with thrombospondin type 1 motif 4; ADAMTS4
- UniProt
- O75173
- 物种
- Human
产品详情
- 靶点名称
- ADAMTS4
- 蛋白名称
- ADAM metallopeptidase with thrombospondin type 1 motif 4
- 蛋白别名
- A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; ADAMTS-4; ADMP-1; Aggrecanase-1
- 靶点基因名
- ADAMTS4
- 基因别名
- KIAA0688
- UniProt
- O75173
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4) is a member of the ADAMTS protein family, characterized by a multi-domain structure including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. This enzyme is primarily known for its role in the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The full-length ADAMTS4 (70 kDa) is the most effective aggrecanase, but it exhibits little activity against the Glu(373)-Ala(374) bond, a signature site of aggrecanase activity. ADAMTS4 is involved in the turnover of aggrecan and may play a critical role in the destruction of aggrecan in arthritic diseases and potentially in neurodegenerative conditions such as Alzheimer's disease. Its expression is upregulated in arthritic disease, contributing to disease progression through the degradation of aggrecan.