人 ADAM8 抗体对
01AB03238
ADAM metallopeptidase domain 8 (ADAM8) is a type I transmembrane, zinc-dependent metalloprotease-disintegrin primarily expressed in immune cells, lymphoid organs, and various tumor cells. The protein undergoes autocatalytic prodomain removal to generate an active sheddase that can release soluble protease fragments into the extracellular matrix. ADAM8 modulates inflammation and cell-matrix interactions by cleaving substrates such as myelin basic protein, CD23, TNF receptor 1, and extracellular matrix proteins including collagen I and fibronectin. Pathologically, ADAM8 is upregulated in inflammatory diseases such as asthma and arthritis, and in various cancers where it promotes tumor invasion and metastasis via MMP-9/LCN2 signaling pathways.
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技术参数
- 靶点基因名
- ADAM8
- 基因别名
- MS2
- 蛋白别名
- ADAM metallopeptidase domain 8; ADAM8
- UniProt
- P78325
- 物种
- Human
产品详情
- 靶点名称
- ADAM8
- 蛋白名称
- ADAM metallopeptidase domain 8
- 蛋白别名
- Disintegrin and metalloproteinase domain-containing protein 8; ADAM 8; Cell surface antigen MS2; CD antigen CD156a
- 靶点基因名
- ADAM8
- 基因别名
- MS2
- UniProt
- P78325
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ADAM metallopeptidase domain 8 (ADAM8) is a type I transmembrane, zinc-dependent metalloprotease-disintegrin primarily expressed in immune cells, lymphoid organs, and various tumor cells. The protein undergoes autocatalytic prodomain removal to generate an active sheddase that can release soluble protease fragments into the extracellular matrix. ADAM8 modulates inflammation and cell-matrix interactions by cleaving substrates such as myelin basic protein, CD23, TNF receptor 1, and extracellular matrix proteins including collagen I and fibronectin. Pathologically, ADAM8 is upregulated in inflammatory diseases such as asthma and arthritis, and in various cancers where it promotes tumor invasion and metastasis via MMP-9/LCN2 signaling pathways.