人 ADAM22 抗体对
01AB01423
ADAM metallopeptidase domain 22 (ADAM22) is a member of the ADAM (A Disintegrin And Metalloprotease) family, which consists of membrane-anchored proteins structurally related to snake venom disintegrins and involved in cell-cell and cell-matrix interactions. ADAM22 is characterized by a disintegrin and metalloprotease-like domain, but it lacks critical catalytic residues, rendering it proteolytically inactive. Its structure includes three calcium-binding sites, with one regulatory and two structural, and features modular movement due to discontinuous hydrophilic interactions between domains. ADAM22 is highly expressed in the brain, where it likely functions as an integrin ligand and plays a role in neurogenesis and synaptic function. Alternative splicing generates multiple transcript variants, and the protein interacts with DLG4, a synaptic scaffolding protein. Clinically, mutations in ADAM22 have been associated with early infantile epileptic encephalopathy (EIEE61).
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技术参数
- 靶点基因名
- ADAM22
- 基因别名
- MDC2
- 蛋白别名
- ADAM metallopeptidase domain 22; ADAM22
- UniProt
- Q9P0K1
- 物种
- Human
产品详情
- 靶点名称
- ADAM22
- 蛋白名称
- ADAM metallopeptidase domain 22
- 蛋白别名
- Disintegrin and metalloproteinase domain-containing protein 22; ADAM 22; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like; disintegrin-like; and cysteine-rich protein 2
- 靶点基因名
- ADAM22
- 基因别名
- MDC2
- UniProt
- Q9P0K1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ADAM metallopeptidase domain 22 (ADAM22) is a member of the ADAM (A Disintegrin And Metalloprotease) family, which consists of membrane-anchored proteins structurally related to snake venom disintegrins and involved in cell-cell and cell-matrix interactions. ADAM22 is characterized by a disintegrin and metalloprotease-like domain, but it lacks critical catalytic residues, rendering it proteolytically inactive. Its structure includes three calcium-binding sites, with one regulatory and two structural, and features modular movement due to discontinuous hydrophilic interactions between domains. ADAM22 is highly expressed in the brain, where it likely functions as an integrin ligand and plays a role in neurogenesis and synaptic function. Alternative splicing generates multiple transcript variants, and the protein interacts with DLG4, a synaptic scaffolding protein. Clinically, mutations in ADAM22 have been associated with early infantile epileptic encephalopathy (EIEE61).