人 ADAM12 抗体对
01AB03208
ADAM metallopeptidase domain 12 (ADAM12) is a zinc-dependent metalloprotease that exists as membrane-bound and secreted isoforms. It is involved in cell adhesion, proteolysis, and signaling, playing key roles in myogenesis, osteoclast formation, and extracellular matrix remodeling. Pathologically, ADAM12 is overexpressed in various cancers, including breast and gastrointestinal malignancies, where it promotes cell migration and invasion. It also contributes to fibrosis and hypertension. Clinically, maternal serum levels of ADAM12 are utilized as a biomarker in prenatal screening for Down syndrome, with reduced levels indicating an increased risk of trisomy 21.
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技术参数
- 靶点基因名
- ADAM12
- 基因别名
- MLTN
- 蛋白别名
- ADAM metallopeptidase domain 12; ADAM12
- UniProt
- O43184
- 物种
- Human
产品详情
- 靶点名称
- ADAM12
- 蛋白名称
- ADAM metallopeptidase domain 12
- 蛋白别名
- Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; Meltrin-alpha
- 靶点基因名
- ADAM12
- 基因别名
- MLTN
- UniProt
- O43184
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ADAM metallopeptidase domain 12 (ADAM12) is a zinc-dependent metalloprotease that exists as membrane-bound and secreted isoforms. It is involved in cell adhesion, proteolysis, and signaling, playing key roles in myogenesis, osteoclast formation, and extracellular matrix remodeling. Pathologically, ADAM12 is overexpressed in various cancers, including breast and gastrointestinal malignancies, where it promotes cell migration and invasion. It also contributes to fibrosis and hypertension. Clinically, maternal serum levels of ADAM12 are utilized as a biomarker in prenatal screening for Down syndrome, with reduced levels indicating an increased risk of trisomy 21.