人 ACYP2 抗体对
01AB03077
Acylphosphatase 2 (ACYP2) is a small, conserved enzyme known as the muscle-type isoform of acylphosphatase. It primarily functions by hydrolyzing acyl-phosphate intermediates and modulating the phosphoenzyme intermediates of membrane pumps, such as the Ca2+/Mg2+-ATPase. It is highly expressed in muscle cells and the cochlea. ACYP2 is involved in pathways related to ATP and ITP metabolism and is essential for maintaining the integrity of cochlear hair cells. Clinically, genetic variations in ACYP2 have been identified as significant factors influencing susceptibility to cisplatin-induced hearing loss, highlighting its importance in pharmacogenomics and auditory health.
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技术参数
- 靶点基因名
- ACYP2
- 基因别名
- ACYP
- 蛋白别名
- acylphosphatase 2; ACYP2
- UniProt
- P14621
- 物种
- Human
产品详情
- 靶点名称
- ACYP2
- 蛋白名称
- acylphosphatase 2
- 蛋白别名
- Acylphosphatase-2; Acylphosphatase; muscle type isozyme; Acylphosphate phosphohydrolase 2
- 靶点基因名
- ACYP2
- 基因别名
- ACYP
- UniProt
- P14621
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Acylphosphatase 2 (ACYP2) is a small, conserved enzyme known as the muscle-type isoform of acylphosphatase. It primarily functions by hydrolyzing acyl-phosphate intermediates and modulating the phosphoenzyme intermediates of membrane pumps, such as the Ca2+/Mg2+-ATPase. It is highly expressed in muscle cells and the cochlea. ACYP2 is involved in pathways related to ATP and ITP metabolism and is essential for maintaining the integrity of cochlear hair cells. Clinically, genetic variations in ACYP2 have been identified as significant factors influencing susceptibility to cisplatin-induced hearing loss, highlighting its importance in pharmacogenomics and auditory health.