人 ACP1 抗体对
01AB04204
Acid Phosphatase 1 (ACP1), encoded by the ACP1 gene on chromosome 2p25.3, is a polymorphic enzyme with dual tyrosine phosphatase and thiamine monophosphatase activities. The protein’s molecular weight is approximately 18 kDa, with structural variability among isoforms affecting enzymatic activity. It exists as three isoforms (F, S, and A) generated by alternative splicing, each differing in substrate affinity and tissue distribution. ACP1 modulates signal transduction by dephosphorylating phosphotyrosine peptides and regulates erythrocyte glucose metabolism. It is implicated in immune responses, influencing T-cell receptor signaling and oxidative stress pathways. Clinically, ACP1 polymorphisms are associated with metabolic disorders, including obesity and type 2 diabetes, potentially through insulin signaling dysregulation. Additionally, altered ACP1 expression has been linked to cancer progression, particularly in leukemia and melanoma, due to its role in cell proliferation and apoptosis.
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技术参数
- 靶点基因名
- ACP1
- 蛋白别名
- acid phosphatase 1; ACP1
- UniProt
- P24666
- 物种
- Human
产品详情
- 靶点名称
- ACP1
- 蛋白名称
- acid phosphatase 1
- 蛋白别名
- Low molecular weight phosphotyrosine protein phosphatase; LMW-PTP; LMW-PTPase; Adipocyte acid phosphatase; Low molecular weight cytosolic acid phosphatase; Red cell acid phosphatase 1
- 靶点基因名
- ACP1
- UniProt
- P24666
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Acid Phosphatase 1 (ACP1), encoded by the ACP1 gene on chromosome 2p25.3, is a polymorphic enzyme with dual tyrosine phosphatase and thiamine monophosphatase activities. The protein’s molecular weight is approximately 18 kDa, with structural variability among isoforms affecting enzymatic activity. It exists as three isoforms (F, S, and A) generated by alternative splicing, each differing in substrate affinity and tissue distribution. ACP1 modulates signal transduction by dephosphorylating phosphotyrosine peptides and regulates erythrocyte glucose metabolism. It is implicated in immune responses, influencing T-cell receptor signaling and oxidative stress pathways. Clinically, ACP1 polymorphisms are associated with metabolic disorders, including obesity and type 2 diabetes, potentially through insulin signaling dysregulation. Additionally, altered ACP1 expression has been linked to cancer progression, particularly in leukemia and melanoma, due to its role in cell proliferation and apoptosis.