抗人 ACLY 抗体对
01AB00635
ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the conversion of citrate to acetyl-CoA, a vital building block for fatty acid and cholesterol biosynthesis, as well as isoprenoid-based protein modifications and histone acetylation. ACLY is a tetramer composed of identical subunits and is activated by insulin. It plays a crucial role in linking carbohydrate metabolism to fatty acid biosynthesis. In cancer cells, ACLY is often upregulated and its inhibition can induce proliferation arrest, making it a potential therapeutic target. Additionally, ACLY contributes to epigenetic regulation through histone acetylation and is involved in innate and adaptive immune responses. Its activity is regulated by phosphorylation at different sites, including Ser455, which increases its enzymatic activity and is crucial for acetyl-CoA production and histone acetylation.
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技术参数
- 靶点基因名
- ACLY
- 蛋白别名
- ATP citrate lyase; ACLY
- UniProt
- P53396
- 物种
- Human
产品详情
- 靶点名称
- ACLY
- 蛋白名称
- ATP citrate lyase
- 蛋白别名
- ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme
- 靶点基因名
- ACLY
- UniProt
- P53396
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the conversion of citrate to acetyl-CoA, a vital building block for fatty acid and cholesterol biosynthesis, as well as isoprenoid-based protein modifications and histone acetylation. ACLY is a tetramer composed of identical subunits and is activated by insulin. It plays a crucial role in linking carbohydrate metabolism to fatty acid biosynthesis. In cancer cells, ACLY is often upregulated and its inhibition can induce proliferation arrest, making it a potential therapeutic target. Additionally, ACLY contributes to epigenetic regulation through histone acetylation and is involved in innate and adaptive immune responses. Its activity is regulated by phosphorylation at different sites, including Ser455, which increases its enzymatic activity and is crucial for acetyl-CoA production and histone acetylation.