抗人 ACE2 抗体对
01AB03929
Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane protein that plays a vital role in the renin-angiotensin-aldosterone system (RAAS), primarily functioning to regulate blood pressure and fluid balance. It catalyzes the conversion of angiotensin II, a potent vasoconstrictor, into angiotensin-(1-7), which promotes vasodilation and counteracts the harmful effects of angiotensin II. ACE2 is characterized by its N-terminal peptidase domain and is widely expressed in various tissues, including the lungs, heart, kidneys, and intestines. Beyond its enzymatic functions, ACE2 serves as a receptor for the SARS-CoV-2 virus, facilitating its entry into host cells during COVID-19 infection. This interaction disrupts ACE2's normal regulatory functions, contributing to inflammation and tissue injury.
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技术参数
- 靶点基因名
- ACE2
- 蛋白别名
- angiotensin converting enzyme 2; ACE2
- UniProt
- Q9BYF1
- 物种
- Human
产品详情
- 靶点名称
- ACE2
- 蛋白名称
- angiotensin converting enzyme 2
- 蛋白别名
- Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme-related carboxypeptidase; ACE-related carboxypeptidase; Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
- 靶点基因名
- ACE2
- UniProt
- Q9BYF1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane protein that plays a vital role in the renin-angiotensin-aldosterone system (RAAS), primarily functioning to regulate blood pressure and fluid balance. It catalyzes the conversion of angiotensin II, a potent vasoconstrictor, into angiotensin-(1-7), which promotes vasodilation and counteracts the harmful effects of angiotensin II. ACE2 is characterized by its N-terminal peptidase domain and is widely expressed in various tissues, including the lungs, heart, kidneys, and intestines. Beyond its enzymatic functions, ACE2 serves as a receptor for the SARS-CoV-2 virus, facilitating its entry into host cells during COVID-19 infection. This interaction disrupts ACE2's normal regulatory functions, contributing to inflammation and tissue injury.