抗人 A1BG 抗体对
01AB02370
Alpha-1-B glycoprotein (A1BG) is a secreted plasma glycoprotein belonging to the immunoglobulin superfamily. Synthesized primarily in the liver, it is a heavily N-glycosylated protein that localizes to the extracellular space and blood microparticles. A1BG forms a high-affinity complex with the cysteine-rich secretory protein CRISP-3, suggesting a role in modulating or protecting specific physiological pathways, although its exact function remains to be fully elucidated. Clinically, A1BG has been identified as a candidate biomarker for several conditions. Altered levels of A1BG or its fragments are reported in pancreatic ductal adenocarcinoma, hepatocellular carcinoma, and pediatric nephrotic syndrome. Its presence in synovial fluid and association with post-myocardial infarction inflammatory responses further highlight its potential relevance in monitoring various disease states.
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技术参数
- 靶点基因名
- A1BG
- 蛋白别名
- alpha-1-B glycoprotein; A1BG
- UniProt
- P04217
- 物种
- Human
产品详情
- 靶点名称
- A1BG
- 蛋白名称
- alpha-1-B glycoprotein
- 蛋白别名
- Alpha-1B-glycoprotein; Alpha-1-B glycoprotein
- 靶点基因名
- A1BG
- UniProt
- P04217
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Alpha-1-B glycoprotein (A1BG) is a secreted plasma glycoprotein belonging to the immunoglobulin superfamily. Synthesized primarily in the liver, it is a heavily N-glycosylated protein that localizes to the extracellular space and blood microparticles. A1BG forms a high-affinity complex with the cysteine-rich secretory protein CRISP-3, suggesting a role in modulating or protecting specific physiological pathways, although its exact function remains to be fully elucidated. Clinically, A1BG has been identified as a candidate biomarker for several conditions. Altered levels of A1BG or its fragments are reported in pancreatic ductal adenocarcinoma, hepatocellular carcinoma, and pediatric nephrotic syndrome. Its presence in synovial fluid and association with post-myocardial infarction inflammatory responses further highlight its potential relevance in monitoring various disease states.