H2AX Antibody, anti-human, PE, REAfinity™

01MT00646

Clone REA1530 recognizes the histone protein H2AX (histone H2A variant X), which is a variant of the core histone H2A that is part of the nucleosome and contributes to the compaction of DNA in chromatin. H2AX plays a particularly important role in the DNA damage response, especially in the case of double-strand breaks. In several tumor types, overexpression of H2AFX/H2AX has been associated with poorer clinical outcomes. For example, in lung adenocarcinoma, high H2AFX expression is associated with an unfavorable prognostic factor. In neuroblastomas, high H2AFX expression correlates with poorer