Glypican 3 Antibody, anti-human, APC, REAfinity™

01MT13987

Clone REA1389 recognizes the human Glypican-3 (GPC3), a cell surface proteoglycan that bears heparan sulfate. Glypican-3 is highly expressed in lung, liver and kidney and overexpressed in overexpressed in different tumors, particularly hepatocellular carcinoma (HCC). Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development and tumor predisposition. Deletion mutations in GPC3 cause Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS).Additional information: Clone REA1389 displays negligible binding to Fc receptors.