FGF-19 (N-6His), Human, Recombinant

05PR00088

产品信息 产品形态 粉末 产品规格 10μg / 50μg / 500μg / 1mg 别名 Fibroblast Growth Factor 19;FGF-19;FGF19 物种 人 表达宿主 E.coli 序列信息 Phe27-Lys216 检索号 O95750 分子量 23.5 kDa 表观分子量 26 kDa 标签 N-6His 纯度 > 95% as determined by reducing SDS-PAGE. 内毒素 < 0.1 EU/μg 储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. 运输条件 Ambient temperature or ice pack. 有效期 12个月 制剂 Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, pH 8.0. 复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 体系描述 GMP生产和质量体系 公司符合cGMP的要求，已通过NMPA的第一类医疗器械生产备案，且通过ISO 13485和ISO 9001标准认证。公司生产的FGF-19 (N-6His), Human, Recombinant符合ISO 9001的cGMP标准。 背景介绍 Fibroblast Growth Factor 19 (FGF19) is a secreted Protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF Receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.