FcεRIα Antibody, anti-human, pure-functional grade

01MT14833

Clone CRA1 detects the α subunit of the human high-affinity Fc receptor for IgE. The receptor is composed of one α-, one β-, and two disulphide-linked γ-chains, of which the α subunit binds IgE1. FcεRIα is expressed on mast and basophil cells, is upregulated in the presence of IgE, and is found on a subset of blood dendritic cells. CRA1 does not inhibit the binding of IgE it induces mast cell activation followed by a histamine release. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.