EPO/Epoetin (C-6His), Human, Recombinant

05PR00028

产品信息 产品形态 粉末 产品规格 10μg / 50μg / 500μg / 1mg 别名 Erythropoietin;Epoetin;EPO 物种 人 表达宿主 Human Cells 序列信息 Ala28-Arg193 检索号 P01588 分子量 19.2 kDa 表观分子量 30-40 kDa 生物活性 Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 80-250 pg/mL. 纯度 > 95% as determined by reducing SDS-PAGE. 内毒素 < 0.1 EU/μg 储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. 运输条件 Ambient temperature or ice pack. 有效期 12个月 制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. 复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 体系描述 GMP生产和质量体系 公司符合cGMP的要求，已通过NMPA的第一类医疗器械生产备案，且通过ISO 13485和ISO 9001标准认证。公司生产的EPO/Epoetin (C-6His), Human, Recombinant符合ISO 9001的cGMP标准。 背景介绍 Erythropoietin (EPO) is a glyco Protein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells.Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated Cytokine composed of fouralpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytescan only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals aremaintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by theliver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation ofsmooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation inerythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These arepathological conditions that develop in numerous tissues and organs as a consequence of diabetesmellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, anddiabetic neuropathy.