EGF Receptor pY845 Antibody, anti-human, APC, REAfinity™

01MT03956

Clone REA439 recognizes the human epidermal growth factor receptor (EGFR) antigen phosphorylated at tyrosine 845 (pY845). EGFR is a single-pass type I membrane protein which is also known as receptor tyrosine-protein kinase ErbB-1 or HER1. It is a critical regulator of many normal cellular processes, including cell growth, differentiation, survival, and migration. The EGFR also is implicated in pathological processes of cellular transformation and oncogenesis due to its overexpression in many types of cancers and its ability to induce morphological transformation of cultured cells and tumor fo