DR3 Antibody, anti-human, Biotin

01MT17146

Clone JD3 recognizes the human DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It mediates activation of NFκB and induces apoptosis. DR3 is expressed preferentially by activated and antigen-experienced T lymphocytes. It is also highly expressed by FoxP3-positive regulatory T lymphocytes. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen-presenting cells and some endothelial cells following