DAP12 Antibody, anti-human, APC, REAfinity™

01MT08618

Clone REA900 recognizes the human DAP12 antigen, a transmembrane signaling polypeptide which consists of an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. DAP12 interacts with several members of the CD300 molecule-like family, CLECSF5 and Siglec14. The association of DAP12 with triggering receptor expressed on myeloid cells (TREM-1) and myeloid DAP12-associating lectin (MDL-1) plays a role in monocytic activation and inflammatory response. DAP12 is found in several tissues, but also in peripheral blood leukocytes.Additional information: Clone REA900 displays n