CliniMACS® CD141 (BDCA-3) Reagent CR/GMP

99MT00379

The CD141 (BDCA-3) antigen is expressed at high levels on a minor subpopulation (about 0.02% of blood leukocytes) of human myeloid/conventional dendritic cells (cDCs). CD141 (BDCA 3)-high blood cDCs are CD11c-dim, CD123–, CD4+, Lin–, CD45RO+, CD2–, and CD16– and express myeloid lineage markers. This population has been designated as type-1 cDCs (cDC1) and has distinct markers from the CD1c (BDCA-1)+ blood DCs population (designated cDC2). Indeed, unlike CD1c (BDCA-1)+ cDC2, CD141 (BDCA-3)-high cDC1 lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. Furthermore, cDC1 differ f