ChemR23 (CMKLR1) Antibody, anti-mouse, APC, REAfinity™

01MT03510

Clone REA461 recognizes the mouse G-protein coupled receptor ChemR23 antigen, a multi-pass membrane protein, which is also known as chemokine-like receptor 1 (CMKLR1). During dendritic cell (DC) differentiation from bone marrow, ChemR23 is upregulated early and then diminishes with time in culture. Most DC in vivo do not detectably express the receptor. In contrast, freshly isolated F4/80+/CD11b+ mouse peritoneal macrophages express ChemR23, display calcium signaling and migration to the active ligand. A small population of blood-borne F4/80+/CD11b+ macrophages also expresses ChemR23. Its natu