CD85d (ILT4) Antibody, anti-human, APC, REAfinity™

01MT13259

Clone REA184 recognizes CD85d, also known as immunoglobulin-like transcript 4 (ILT4) or leukocyte Ig-like receptor 2 (LIR2). CD85d is an inhibitory immunoreceptor, expressed mainly on myelomonocytic lineage cells.CD85d has four tandem Ig-like extracellular domains and three immunoreceptor tyrosine-based inhibitory receptor motifs in its cytoplasmic tails, which recruit the tyrosine phosphatase Src homology 2 domain containing phosphatase 1 (SHP-1). It has been shown that CD85d interacts with HLA-A, -B, -G1, and -E molecules as ligands. HLA-G expression is restricted to trophoblasts and thus in