CD74 Antibody, anti-human, APC

01MT16708

Clone 5-329 recognizes CD74, a non-polymorphic type II integral membrane protein. CD74 is also known as MHC class II–associated invariant chain and exists in multiple isoforms in human ranging from 33 to 43 kDa in size. Initially known for its role as the MHC II chaperone, CD74 primary function is suggested to regulate the MHC class II molecules folding and intracellular sorting. Recent studies however suggest further roles of CD74. It interacts with cytokine-like molecule called macrophage migration- inhibitory factor (MIF) and induce ERK1 and ERK2 signaling in a CD44 dependent manner. CD74 i