CD49c Antibody, anti-human, APC, REAfinity™

01MT02991

Clone REA360 recognizes the human CD49c antigen, a single-pass type I membrane protein also known as integrin α-3 (ITGA3) or VLA-3α. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c/CD29, VLA-3) and plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. It is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. CD49c/CD29 plays a role in cell-cell and cell-matrix adhesion through binding fibronectin, laminin, collagen, epiligrin, th