CD40 Antibody, anti-mouse, APC, REAfinity™

01MT09872

Clone REA965 recognizes the mouse CD40 antigen, a 40–50 kDa glycoprotein and member of the tumor necrosis factor receptor (TNFR) family. CD40 is expressed on B lymphocytes, macrophages, and dendritic cells. It is an important costimulatory molecule for B cells as well as dendritic cells, monocytes, and other antigen-presenting cells (APCs). The interaction of CD40 on B cells with its ligand CD154 is involved in B cell activation and differentiation; engagement of CD40 on dendritic cells leads to maturation. Additional information: Clone REA965 displays negligible binding to Fc receptors.