CD274 (PD-L1) Antibody, anti-human, PE, REAfinity™

01MT13523

Clone REA1308 recognizes the human CD274 antigen, also known as programmed cell death 1 ligand 1 (PD-L1). CD274 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. It functions as an immune inhibitory receptor ligand which is involved in the costimulatory signal, essential for T cell proliferation and production of interleukin 10 (IL-10) and interferon γ (IFN-γ). CD274 and PD-1 (programmed death 1) belong to the immune checkpoint pathway and are suggested to be potential markers in human cancers.CD274 is expressed on activated T cells, B cells, dendritic cells