CD273 (PD-L2) Antibody, anti-mouse, APC

01MT16260

Clone MIH37 recognizes CD273, a member of the B7 family of protein ligands. CD273, along with another member of the B7 family (B7-H1) are ligands of T-cell receptor known as programmed death-1 (PD-1). Surface expression of B7-DC is restricted to dendritic cells (DCs) and activated or IFNγ-stimulated DCs and macrophages. CD273/PD-1 interaction is involved in inhibition of T-cell activation, however a co-stimulatory role of CD273, via interaction with receptor other then PD-1 is also reported.