CD246 (ALK) Antibody, anti-human, Biotin, REAfinity™

01MT00820

Clone REA425 recognizes both the normal human CD246 and the nucleolar protein nucleophosmin-CD246 (NPM-CD246) chimeric antigen. CD246 is a single-pass type I membrane protein which is also known as anaplastic lymphoma kinase (ALK). It is a neuronal orphan receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-CD246 gene. CD246 plays an important role in the genesis and differentiation of the nervous system. It is essentially and transiently expressed in specific regions of the central and pe