CD234 (DARC) Antibody, anti-human, APC, REAfinity™

01MT03223

Clone REA376 recognizes the human CD234 antigen, a multi-pass membrane protein also known as duffy antigen receptor for chemokines (DARC) or Fy glycoprotein (FY). CD234 is responsible for the duffy blood group system and belongs to a family of silent seven-transmembrane spanning receptors, which do not couple to G-proteins and therefore do not transmit intracellular signals like other G-protein–coupled chemokine-receptors leading to integrin activation or cell motility. It binds to a broad range of inflammatory chemokines of both the CC and the CXC chemokine families, but does not interact wit