CD229 (Ly-9) Antibody, anti-human, PE, REAfinity™

01MT09163

Clone REA963 recognizes the human CD229 antigen, a type I transmembrane glycoprotein belonging to the CD150 subfamily of leukocyte receptors of the Ig superfamily. CD229, also known as Ly-9, has four extracellular Ig domains and a cytoplasmic domain containing two copies of the tyrosine-based motif (T-I/V-Y-x-x-V/I). Via this unique motif, CD229 interacts with SH2-binding phosphatases and the adapter molecules SAP, EAT-2, and Grb2. Expression of CD229 is found on T cells, B cells, NK cells, and thymocytes. CD229 interacts homophilically via its N-terminal V-like domain and is involved in enhan