CD223 Antibody, anti-mouse, APC, REAfinity™

01MT06809

Clone REA776 recognizes an epitope within the D2 domain of murine CD233, also known as LAG-3, which is a 70 kDa high affinity MHC class II ligand. It is expressed on activated CD4+ and CD8+ α/β T cells, on a subset of NK cells, B cells and plasmacytoid dendritic cells. It is proposed, that LAG-3 could be used as a marker of T cell induced B cell activation.In association with the CD3 complex CD223 is a negative regulatory molecule to inhibit TCR-mediated signaling and to regulate homeostatic T cell expansion.Additional information: Clone REA776 displays negligible binding to Fc receptors