CD222 Antibody, anti-human, PE, REAfinity™

01MT01606

Clone REA187 recognizes CD222, a 300 kDa type I transmembrane protein, which serves as a multifunction receptor and is ubiquitously expressed. CD222 has a large extracytoplasmic domain, a single transmembrane region, and a short cytoplasmic tail that lacks intrinsic catalytic activity. The receptor cycles continuously between intracellular compartments and the plasma membrane. At steady state, CD222 is found mainly intracellularly, and to a lesser extent on the cell surface. CD222 binds IGF-2 and mannose-6 phosphate containing ligands such as transforming growth factor‐β, leukemia inhibitory