CD220 Antibody, anti-human, Biotin, REAfinity™

01MT02129

Clone REA260 recognizes the CD220 antigen, a type I transmembrane receptor tyrosine kinase, which is also known as insulin receptor (IR). CD220 is predominantly expressed in major target tissues of insulin metabolic effects like liver, adipose tissue, and skeletal muscle, but is also expressed in the peripheral nerve, kidney, fibroblasts, monocytes, granulocytes, erythrocytes, and skin. It is composed of two extracellular α-subunits and two transmembrane β-subunits. Upon binding of insulin, CD220 forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine k