CD218 (IL-18Rα) Antibody, anti-human, Vio® Bright V423, REAfinity™

01MT11575

Clone REA1095 recognizes the CD218 antigen, which is also known as interleukin-18 receptor alpha (IL-18Rα) chain. IL-18 receptor is an heterodimeric receptor complex, and composed of the IL-18Rα chain and the IL-1 receptor accessory protein-like (IL-1RacPL) or IL-18Rβ chain. CD218 represents the ligand-binding chain, whereas IL-18Rβ is suggested to assist in the formation of a high affinity complex and mediates intracellular signals. IL-18R is expressed on a variety of cells including macrophages, neutrophils, natural killer (NK) cells, endothelial, and smooth muscle cells and an upregulated e