CD21 (CR2) Antibody, anti-human, PE, REAfinity™

01MT13880

Clone REA1408 recognizes the human CD21 (CR2) antigen, a type I membrane glycoprotein. Expression of CD21 (CR2) in humans is found on B cells, follicular dendritic cells, subsets of epithelial cells, and thymic T cells. The primary function attributed to CD21 (CR2) has been to amplify the B cell receptor (BCR)-mediated signal transduction in response to antigen recognition. To enhance the BCR mediated activation, CD21 (CR2) associates with CD19 and CD81 in a B cell–specific signal transduction complex, where interaction of BCR with CR2/CD19 amplifies the signals. In addition, CD21 (CR2) serves