CD197 (CCR7) Antibody, anti-mouse, APC

01MT16806

Clone 4B12 reacts with CD197 (CCR7), a chemokine receptor for chemokines CCL19 and CCL21. CD197, like other chemokine receptors, has seven-transmembrane spanning domains and signals via G proteins. Expression of CD197 is found on semi-mature and mature dendritic cells (DCs), naive B and T cells, regulatory T (Treg) cells, a subpopulation of T cells called central memory T cells, and non-immune malignant cells. CD197 is involved in regulating homing of immune cells, immunity to pathogens, immune tolerance, development and function of Tregs, and manifestation of autoimmunity.