CD194 (CCR4) Antibody, anti-human, APC, REAfinity™

01MT10422

Clone REA279 recognizes the CD194 antigen, a seven-transmembrane G-protein–coupled receptor also known as C-C chemokine receptor type 4 (CCR4). CD194 is expressed on activated Tʜ2 cells, regulatory T cells, a subset of B cells, activated natural killler (NK) cells, basophils, monocytes, NK cells, and platelets. It is expressed at high levels by skin-infiltrating lymphocytes, at lower levels by lung and synovial fluid lymphocytes, but never by intestinal lymphocytes. CD194 is the specific receptor for the chemokines CCL17 (TARC) and CCL22 (MDC). Human peripheral blood regulatory T cells can be