CD182 (CXCR2) Antibody, anti-mouse, APC, REAfinity™

01MT09014

Clone REA942 recognizes the mouse CD182 (CXCR2) antigen, which belongs to the class of chemokine receptors specific for CXC chemokines. Chemokine receptors are G-coupled protein receptors (GPCR) with seven-transmembrane domains and consist of an α-subunit and a βγ-complex.Mouse knockout studies have shown that CD182 (CXCR2) gene inactivation results in several abnormalities including lymphadenopathy and splenomegaly. CD182 (CXCR2) binds several CXCL8-like CXC chemokines, e.g. CXCL1/cytokine-induced neutrophil-attracting cytokine (KC), macrophage inflammatory protein (MIP)-2 and CXCL6/granulocy