CD146 Antibody, anti-human, APC, REAfinity™

01MT05602

Clone REA773 recognizes the human CD146 antigen, also known as MUC18, MCAM, Mel-CAM, or S-Endo-1. CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)-like domains. CD146 possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes. CD146 is also expressed on marrow stromal cells (MSCs). CD146 functions as a Ca2+-independent cell adhesion molecule that is involved in heter