CD143 (ACE) Antibody, anti-human, PE, REAfinity™

01MT04283

Clone REA522 recognizes the human CD143 antigen, a single-pass type I membrane protein, which is also known as angiotensin-converting enzyme (ACE). CD143, which exists in two isoforms (a 170 kDa somatic form and a 90 kDa germinal form), is part of the renin-angiotensin system (RAS), and increases blood pressure by causing blood vessels to constrict. It is secreted by cells in the endothelium of blood vessels in lungs and kidneys. The function of CD143 is to catalyse the conversion of angiotensin I to angiotensin II, which are also part of RAS. CD143 is highly regulated in different diseases, f