CD140b Antibody, anti-mouse, PE

01MT14991

Clone APB5 reacts with the transmembrane glycoprotein CD140b, the β-chain of the platelet-derived growth factor receptor (PDGFR). The two isoforms of the receptor can form homodimers (α/α or β/β) or heterodimers (α/β). Receptor dimerization and transphosphorylation at tyrosine residues activates the intracellular kinase activity. CD140b has been reported to be broadly expressed in embryonic tissue, mostly in cells of mesodermal origin in adult tissue. Expression of CD140a is associated with various malignancies.