CD135 (FLT3) Antibody, anti-human, PE, REAfinity™

01MT06912

Clone REA786 recognizes the human CD135 antigen, a single-pass type I membrane protein also known as Fms-like tyrosine kinase receptor 3 (FLT3) or fetal liver kinase-2 (FLK-2). CD135 belongs to the same family as FMS, KIT, and the two genes encoding PDGFRα and β. CD135 is normally expressed by hematopoietic stem and progenitor cells and expression is lost as hematopoietic cells differentiate. Although, CD135 expression is usually lost upon hematopoietic stem cell (HSC) differentiation, dendritic cells are an exception, as mature dendritic cells (DCs) display persistent FLT3 expression. CD135 i