CD127 (IL-7Rα) Antibody, anti-human, APC, REAfinity™

01MT14005

Clone REA1394 recognizes the CD127 (IL-7Rα) antigen, which is the α-chain of the IL-7 receptor, a type I membrane glycoprotein. Signaling of IL-7 through the IL-7R requires both IL-7Rα and the common cytokine gamma chain (γc).1 CD127 (IL-7Rα) can be identified on immature B cells through the early pre-B stage, on thymocytes, and on most mature T cells with transient down-regulation upon activation. On regulatory T cells CD127 (IL-7Rα) is absent and its expression is inversely correlated with FoxP3 expression and suppressive function. CD127 (IL-7Rα) is also used by thymic stromal derived lympho