CD116 Antibody, anti-human, APC, REAfinity™

01MT01640

Clone REA211 recognizes CD116, the α subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific α subunit, CD116, and βc subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 r