CD112 Antibody, anti-human, Biotin

01MT17686

Clone R2.525 recognizes the human CD112 antigen, a single-pass type I membrane protein, which is also known as nectin-2, herpesvirus entry mediator B (HveB), or poliovirus receptor-related protein 2 (PRR2). Nectins are Ca2+-independent cell adhesion molecules that consist of 4 members: CD111 (Nectin-1), CD112 (Nectin-2), CD113 (Nectin-3), and Nectin-4. CD112 is one of the plasma membrane components of adherens junctions and is widely expressed in human tissues, including hematopoietic cells. It is also over-expressed in various cancers, e.g. breast and ovarian cancers. It has been reported to