CD106 (VCAM-1) Antibody, anti-mouse, APC, REAfinity™

01MT09563

Clone REA971 recognizes the mouse CD106 antigen, a 110 kDa single-chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow cells, stromal cells, and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal tran