c-Met (HGFR) Antibody, anti-human, PE, REAfinity™

01MT13864

Clone REA1397 recognizes c-Met (HGFR), the human c-Met single pass tyrosine-protein kinase, which binds its ligand Hepatocyte Growth Factor (HGF). c-Met is involved in different physiological processes including proliferation, scattering, morphogenesis and survival. c-Met is mainly expressed in endothel and epithelial cells and is encoded by MET, which is a protooncogen. Mutations in MET have been implicated in the development of several malignancies, e.g. renal cell carcinoma (RCC), lung cancers, hepatocellular tumors and cancers of stomach, breast, and brain.