BATF Antibody, anti-human, APC, REAfinity™

01MT04050

Clone REA486 recognizes the human B cell–activating transcription factor (BATF) antigen, a 14 kDa transcription factor belonging to the AP-1 family of basic leucine zipper transcription factors. BATF plays an important role in regulating differentiation and function in many lymphocyte lineages. In the CD8+ T cell lineage, increased expression of BATF in exhausted CD8+ T cells suppresses their effector function. In the CD4+ T cell lineage, BATF is required for the differentiation of interleukin 17 producing helper T cells, where it binds cooperatively with the transcription factor IRF4 and its