抗 ZXDC 磁珠
02AB00073
Zinc finger protein ZXDC (ZXDC) is a transcription factor characterized by its two C2H2-type zinc finger domains, which facilitate DNA binding and transcriptional regulation. It plays a crucial role in the activation of major histocompatibility complex (MHC) class I and II genes by interacting with the class II transactivator (CIITA). ZXDC is involved in various biological processes, including immune responses, cell proliferation, and differentiation. Its expression is regulated by factors such as hypoxia and cytokines, highlighting its role in cellular adaptation to environmental changes. ZXDC has been linked to cancer progression, particularly through its interactions with key proteins like p53 and GSK3β, suggesting its involvement in tumorigenesis. Additionally, dysregulation of ZXDC may contribute to autoimmune diseases, making it a potential target for therapeutic interventions in both cancer and immune-related disorders.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- ZXDC
- 基因别名
- ZXDL
- 蛋白别名
- ZXD family zinc finger C; ZXDC
- UniProt
- Q2QGD7
- 物种
- Human, Mouse
- 应用
- IP
产品详情
- 靶点名称
- ZXDC
- 蛋白名称
- ZXD family zinc finger C
- 蛋白别名
- Zinc finger protein ZXDC; ZXD-like zinc finger protein
- 靶点基因名
- ZXDC
- 基因别名
- ZXDL
- UniProt
- Q2QGD7
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Mouse
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
SDDPLALTSNSNLAAHITTPTSSSTPRENASVPELLAPIKVEPDSPSRPGAVGQQEGSHGLPQSTLPSPAEQHGAQDTELSAGTGNFYLESGGSARTDYRAIQLAKEKKQRGAGSNAGASQSTQRKIKEG
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Zinc finger protein ZXDC (ZXDC) is a transcription factor characterized by its two C2H2-type zinc finger domains, which facilitate DNA binding and transcriptional regulation. It plays a crucial role in the activation of major histocompatibility complex (MHC) class I and II genes by interacting with the class II transactivator (CIITA). ZXDC is involved in various biological processes, including immune responses, cell proliferation, and differentiation. Its expression is regulated by factors such as hypoxia and cytokines, highlighting its role in cellular adaptation to environmental changes. ZXDC has been linked to cancer progression, particularly through its interactions with key proteins like p53 and GSK3β, suggesting its involvement in tumorigenesis. Additionally, dysregulation of ZXDC may contribute to autoimmune diseases, making it a potential target for therapeutic interventions in both cancer and immune-related disorders.